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目的:探讨长方案超促排卵中卵巢反应不良者与反应正常者临床状况的差异,为更好地预测卵巢反应不良提供依据。方法:回顾性分析568个采用长方案超促排卵的IVF-ET周期,其中发生卵巢反应不良44例,卵巢反应正常524例,比较两组患者年龄、基础雌二醇(E2)、基础卵泡雌激素(FSH)、窦卵泡数、获卵数。结果:两组患者年龄、基础E2、窦卵泡数、获卵数差异均有统计学意义(P<0.001)。卵巢反应不良组年龄明显高于正常组,基础E2卵巢反应不良组明显高于正常组,窦卵泡数卵巢反应不良组明显少于正常组。获卵数卵巢反应不良组明显少于正常组。结论:患者年龄、基础E2、窦卵泡对预测卵巢反应不良有一定意义,其中窦卵泡数可以更准确地预测卵巢反应不良。
OBJECTIVE: To investigate the differences in the clinical status of patients with poor ovarian response and normal response to long-term hyperstimulation in order to provide evidence for better prediction of poor ovarian response. Methods: A retrospective analysis of 568 IVF-ET cycles with long-term ovulation hyperstimulation showed that 44 cases had ovarian dysfunction and 524 cases had normal ovarian response. The age, basal estradiol (E2) Hormones (FSH), antral follicles, number of oocytes. Results: There were significant differences in age, basal E2, antral follicle count and number of oocytes retrieved between the two groups (P <0.001). The age of poor ovarian response group was significantly higher than the normal group, basal E2 ovarian dysfunction group was significantly higher than the normal group, antral follicle count ovarian dysfunction group was significantly less than the normal group. Oviparous ovarian failure group was significantly less than the normal group. CONCLUSIONS: Age, basal E2, and antral follicles have some implications for predicting poor ovarian response, with antral follicles more predictive of ovarian dysfunction.