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药理作用极端复杂,而临床应用又非常广泛的药物,当首推氯硫二苯胺(chlorpromazine)。近年来临床应用的结果,获得卓越的疗效。国内亦有文献的报告。我军部份医院业已采用,目前我国已能生产。本文对此药物的药理学及临床应用特作一概括性的重点介绍,以供参考,全面细致的探讨限于篇幅,恐亦无必要。氯硫二苯胺是苯噻嗪(Phenethiazine)的衍化物,Char-Pentier 于1950年12月在 Rhone-Pouleuc研究所综合成功,最早在法国以“4560R.P.”的商品名称问世,其他各国称为,Largactil,Megaphen,Hibernal,Thorazine(S.K.F.2601-A),Ampliactil,Amplictil,Wintermin,Chior-promasine 等。Laborit 等首先应用于“人工冬眠木”以及与啶合用于临床麻醉,1952年 Delay 和Deniker 两氏报告它对于精神病的疗效.
Extremely complex pharmacological effects, and the clinical application of a very wide range of drugs, when the most important chlorpromazine (chlorpromazine). In recent years, the clinical application of the results, access to superior efficacy. There are also domestic literature reports. Some hospitals in our army have already adopted and at present China has been able to produce. This article on the pharmacology and clinical application of this drug special make a general introduction, for reference, a comprehensive and meticulous discussion of space limitations, fear is not necessary. Chlorothiadiphenylamine, a derivative of Phenethiazine, was successfully synthesized at the Rhone-Pouleuc Institute in December 1950 and was first introduced under the trade name “4560R.P.” In France. Other The countries are called Largactil, Megaphen, Hibernal, Thorazine (SKF2601-A), Ampliactil, Amplictil, Wintermin, Chior-promasine and the like. Laborit et al. First applied to “Artificial Hibernation Wood” and combined with clonidine for clinical anesthesia. In 1952, Delay and Deniker Both reported its efficacy in the treatment of mental illness.