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目的:分析HIV/AIDS并发活动性结核感染患者的临床特点,探讨HIV并发结核的发生与患者免疫状态的相关性,为做好HIV/AIDS并发活动性结核患者的治疗与管理提供科学依据。方法:回顾性分析12例HIV/AIDS并发活动性结核患者的病例资料,对临床表现、CD4+T淋巴细胞、PPD、ESR、TBAb及结核蛋白芯片等实验室检查结果进行分析,将所有资料数值用EXCEL建立数据库。结果:本研究共收集HIVAIDS并发活动性结核患者12例,HIV合并结核患者临床表现多样,以体重减轻和发热为主;男女患病率1.4∶1,中位年龄(41.25±8.23)岁,感染途径多以血液及性传播为主;实验室检查PPD、ESR、TBAb及结核蛋白芯片阳性率较低;HIV/AIDS并发活动性结核感染时患者的CD4+T淋巴细胞显著减少,均值为(134.8±153.4)×106/L。结论:HIV/AIDS并发活动性结核患者临床表现多样,免疫力低下,应加强对这类患者的筛查。
OBJECTIVE: To analyze the clinical features of HIV / AIDS patients with active TB infection and to explore the correlation between the occurrence of HIV concurrent TB and the immune status of patients, so as to provide a scientific basis for the treatment and management of HIV / AIDS complicated with active tuberculosis. Methods: A retrospective analysis of 12 cases of HIV / AIDS complicated with active tuberculosis patients, clinical manifestations, CD4 T lymphocytes, PPD, ESR, TBAb and TB protein chip laboratory test results were analyzed, all data values Use EXCEL to build the database. Results: A total of 12 HIV / AIDS patients with active tuberculosis were collected in this study. The clinical manifestations of HIV co-infected patients were diverse, with weight loss and fever mainly. The prevalence of men and women was 1.4: 1, and the median age was 41.25 ± 8.23 years. The main pathways were blood and sexually transmitted. The positive rates of PPD, ESR, TBAb and TB protein chip in laboratory were low. The CD4 + T lymphocytes in HIV / AIDS patients with active TB infection were significantly decreased (mean, 134.8% ± 153.4) × 106 / L. Conclusion: The clinical manifestations of HIV / AIDS patients with active tuberculosis are diverse and their immunity is low. Screening for such patients should be strengthened.