癌症的发生是一个多基因决定和多阶段演进的过程 ,首先是某些基因发生突变并不断积累 ,引起细胞分化生长失控。然而这些突变必须克服机体设置的细胞增殖障碍、应激产生的染色体基因修补机制以及多种抑癌基因的作用。在染色体受到损伤时 ,这些抑癌因子会激活表达 ,调控基因转录 The occurrence of cancer is a process of multi-gene determination and multi-phase evolution. First, some genes are mutated and accumulate, causing the cells to grow out of control. However, these mutations must overcome the cell proliferation barriers set by the body, the chromosomal gene repair mechanisms caused by stress, and the role of various tumor suppressor genes. When chromosomes are damaged, these tumor suppressor factors activate expression and regulate gene transcription.