论文部分内容阅读
目的:探讨一种新型的全脑全脊髓放疗技术的临床疗效及安全性.方法:回顾性分析2012-12/2015-08第四军医大学唐都医院收治的26例中枢神经系统肿瘤患者的临床资料,术后采用全脑三维适形及全脊髓调强放疗技术,观察放疗期间的不良反应、近期疗效及安全性.结果:放疗期间,23.0%(6/26)的患者出现白细胞下降,血小板下降,恶心、乏力、纳差症状;放疗结束后1月,疗效评价CR 23.0%(6/26),PR3.8%(1/26),有效率为26.8%(7/26).随访日期截止为2016年8月,19.2%(5/26)的患者出现颅内肿瘤播散而死亡,在照射野衔接处未出现复发或急慢性脊髓损伤.结论:全脑适形及全脊髓调强放疗技术治疗中枢神经系统肿瘤,放疗剂量分布均匀,安全性良好,早期及晚期副反应均可接受.
Objective: To investigate the clinical efficacy and safety of a new type of whole brain spinal cord radiotherapy.Methods: The clinical data of 26 patients with central nervous system tumors admitted to Tangdu Hospital of the Fourth Military Medical University between Dec 2012 and Aug 2015 were retrospectively analyzed. Data, postoperative whole-brain 3D conformal and whole-spine IMRT was used to observe the adverse reaction, short-term curative effect and safety during radiotherapy.Results: During the radiotherapy, 23.0% (6/26) patients had leukopenia, Decreased, nausea, fatigue and anorexia symptoms; after the end of radiotherapy in January, the efficacy evaluation CR 23.0% (6/26), PR 3.8% (1/26), the effective rate was 26.8% (7/26) As of August 2016, 19.2% (5/26) of patients died of intracranial tumor dissemination and no recurrence or acute or chronic spinal cord injury occurred at the junction of irradiation field.Conclusion: Radiotherapy for the treatment of central nervous system tumors, radiation dose uniformity, good safety, early and late side effects are acceptable.