恶性黑色素瘤(malignant melanoma)发生率占全身肿瘤的1％,发生在鼻腔者更属罕见,我院建院30余年仅见6例。临床易误诊、漏诊,无色素性恶性黑色素瘤病理诊断更是困难,本组6例临床资料较齐全,病理检验亦较详细,并有免疫组织化学和透射电镜观察结果。1 临床资料男4例,女2例,最小年龄47岁,最大年龄76岁。病程2个月至1a,4例病程在3个月以上。主要症状为鼻堵(6/6)、鼻(鼻丑)(4/6),其他症状为头痛,耳鸣、耳聋等。鼻 The incidence of malignant melanoma is 1% of the total body tumors, and it is even rarer in the nasal cavity. In our hospital for more than 30 years, only 6 cases have been seen. Misdiagnosis and misdiagnosis in clinic are often misdiagnosed. The pathological diagnosis of non-pigmented malignant melanoma is even more difficult. The clinical data of 6 patients in this group were relatively complete, and the pathological examination was also more detailed. Immunohistochemistry and transmission electron microscopy were also observed. 1 The clinical data were 4 males and 2 females. The minimum age was 47 years and the maximum age was 76 years. The disease duration ranged from 2 months to 1 year, and the duration of the 4 cases was more than 3 months. The main symptoms are nasal obstruction (6/6), nasal (nasal ugly) (4/6), and other symptoms are headache, tinnitus, deafness and so on. nose