目的观察奥美拉唑三联疗法治疗消化性溃疡的疗效,寻找一种正规高效适合基层医院使用的治疗PU和根除HP的方案。加强基层医生对Hp治疗知识的普及与更新。方法将经胃镜证实的123例消化性溃疡患者随机分成治疗组和对照组。治疗组63例(A组)应用奥美拉唑20mg2次/d口服,疗程4周;阿莫西林1·0BidPo,克拉霉素0·5BidPo,疗程一周。对照组60例(B组)应用奥美拉唑20mgBidPo疗程4周,阿莫西林1·0BidPo,甲硝唑0·4BidPo,疗程一周。结果溃疡治愈率A组总有效率为100%,Hp清除率95%;B组总有效率为93%,Hp清除率89%。2月后随诊所有患者,治疗组溃疡复发率为2%,对照组为19%。两组比较差异有统计学意义(P<0·05)。结论奥美拉唑、阿莫西林、克拉霉素、三联治疗PU和根除Hp疗效确切。该方法简单、高效、依从性好,不良反应少,溃疡复发率低。 Objective To observe the efficacy of omeprazole triple therapy in the treatment of peptic ulcer and to find a regimen for the treatment of PU and eradication of HP which is suitable for the primary hospitals with high efficiency. Strengthen the grassroots doctors on the popularity of Hp treatment knowledge and update. Methods 123 patients with peptic ulcer confirmed by endoscopy were randomly divided into treatment group and control group. The treatment group, 63 cases (A group) omeprazole 20mg2 times / d orally for 4 weeks; amoxicillin 1.0BidPo, clarithromycin 0. 5BidPo, a week. The control group of 60 patients (group B) omeprazole 20mgBidPo treatment for 4 weeks, amoxicillin 1.0BidPo, metronidazole 0. 4BidPo, a week. Results The ulcer cure rate was 100% in group A and 95% in Hp. The total effective rate in group B was 93% and the clearance rate of hp was 89%. All patients were followed up after 2 months. The recurrence rate of ulcer in the treatment group was 2% and that in the control group was 19%. The difference between the two groups was statistically significant (P <0.05). Conclusion Omeprazole, amoxicillin, clarithromycin, triple therapy PU and eradication of Hp exact effect. The method is simple, efficient, good compliance, less adverse reactions, ulcer recurrence rate is low.