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目的 探讨血管紧张素转换酶 (ACE)基因多态性与冠状动脉粥样硬化的关系。方法 14 6例冠心病(CAD)患者按ACE基因型分为缺失型纯合子 (DD)、杂合子 (ID)及插入型纯合子 (II) 3组 ;Bogaty标准评价冠状动脉造影结果 ;马尿酸微量比色法测量血清ACE水平。结果 ⑴Bogaty各指标评价结果与左室射血分数 (LVEF)及左室舒张末压 (LVEDP)明显相关。⑵DD型CAD患者冠脉病变较ID及II型严重。⑶DD型CAD患者血清ACE水平高于ID及II型。结论 ⑴ACE基因多态性与CAD患者冠状动脉病变有关。⑵血清ACE水平可能为二者相关的机制。⑶Bogaty标准能全面准确地反映CAD患者冠状动脉病变特征及左室功能下降程度。
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and coronary atherosclerosis. Methods 14 patients with coronary heart disease (CAD) were divided into three groups: deletion homozygous (DD), heterozygous (ID) and homozygous (II) homozygous according to ACE genotype; Bogaty criteria for coronary angiography; hippuric acid Serum ACE levels were measured by microcolorimetry. Results ⑴Bogaty index evaluation results and left ventricular ejection fraction (LVEF) and left ventricular end-diastolic pressure (LVEDP) were significantly related. Â ’¡type CAD patients with coronary lesions than ID and type II serious. Serum ACE levels in patients with CDD type CAD were higher than ID and type II. Conclusion ⑴ ACE gene polymorphism and CAD patients with coronary artery lesions. ⑵ serum ACE levels may be related to the two mechanisms. ⑶Bogaty standard can fully and accurately reflect the characteristics of CAD patients with coronary lesions and decreased left ventricular function.