Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures

来源 :中国化学会第三届全国生物物理化学会议暨国际华人生物物理化学发展论坛 | 被引量 : 0次 | 上传用户:wenjun_wu
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A combination of ab initio calculations,circular dichroism,nuclear magnetic resonance and X-ray photoelectron spectroscopy has shown that aluminum ions can induce the formation of backbone ring structures in a wide range of peptides,including neurodegenerative disease related motifs.These ring structures greatly destabilize the protein and result in irreversible denaturation.This behavior benefits from the ability of aluminum ions to form chemical bonds simultaneously with the amide nitrogen and carbonyl oxygen atoms on the peptide backbone.
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