Inhibition of cystathionine β-synthetase desensitizes sodium channel activities of dorsal root gangl

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户:zhouyiai1015
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Background: The pathogenesis of pain in lumber disc herniation (LDH) remains poorly understood.We have previously reported that voltage-gated sodium channels (VGSCs) in dorsal root ganglion (DRG) neurons were sensitized in a rat model of LDH.
其他文献
Objective Neuropathic pain (NP) is a complex, chronic painful disease and most of them are still an intractable painful disease of worldwide even at present.Post-herpetic neuralgia (PHN) is one of typ
会议
Background: Our previous research suggested that the microglial P2X4 purinoceptor (P2X4R) is involved in the activation of toll-like receptor-4 (TLR4) and the release of brain-derived neurotrophic fac
Neuropeptide substance P (SP) is both produced and released by a subset of peripheral sensory neurons that respond to tissue damage (nociceptors);these neurons also express SP receptors (NK1-3).SP exe
会议
Bone cancer pain resulting from primary tumors or tumors that metastasize to bone is one of the most severe and intractable types of cancer pain, which reduces the quality of the cancer patients life.
The large-conductance Ca2+-and voltage-gated K+ channels or BK channels are ubiquitously expressed throughout the central nervous system including the cingulate cortex and contribute to action potenti
会议
Objective Na+,K+-ATPase (NKA) is required to generate the resting membrane potential in neurons.Our previous study showed that activation of NKA in dorsal root ganglin (DRG) neurons by follistatin-lik
Mitochondria are the most important organelles in neurons with essential functions, yet very little research has addressed on its potential role in pain.
Mitogen-activated protein kinases (MAPK)-mediated chemokine-cytokine networks in glial cells are likely involved in the pathological process of spinal central sensitization, the basic mechanism underl
Objective Fibroblast growth factor (FGF) 7, a member of FGF family, is initially found to be secreted from mesenchymal cells to repair epithelial tissues.However, its functions in the nervous system a
The contributions of gasotransmitters to itch sensation are largely unknown.In this study, we aimed to investigate the roles of hydrogen sulfide (H2S), a ubiquitous gasotransmitter, in itch signaling.