• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Using Imputation Method with reference panel reconstruction to Improve Whole Exome Sequencing analys

Using Imputation Method with reference panel reconstruction to Improve Whole Exome Sequencing analys

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：xiaoshancx
【摘 要】
：
　　Background: With the advances of Next Generation Sequencing technology, the application of bioinformatics to solve genomics problem become a focus of recent
【作 者】
：
裴智勇 李雪楠 周家蓬 桂小柯 陈禹保 
【机 构】
：
生物计算事业部,北京市计算中心,北京科学技术研究院,北京,100094;北京基因组研究所,中国科学院,北京,100101生物计算事业部,北京市计算中心,北京科学技术研究院,北京,100094
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年10期
【关键词】
：
Bioinformatics Imputation Whole exome sequencing 1000 Genomes Project Reference 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　Background: With the advances of Next Generation Sequencing technology, the application of bioinformatics to solve genomics problem become a focus of recent research.The accumulation of human genetic variation data make it feasible to utilize computational method to improve the analysis, such as using imputation to improve the performance in Whole Exome Sequencing (WES) analysis.
其他文献
Splicing Abnormalities in Tumors and Cancer Cell Lines
　　Almost all cancer-driving events are exerted through altered transcriptional states: abnormal expression levels, mutation-carrying transcripts, gene fusions
会议
Selection of mixed linear modeling for analysis of technical and biological variations in RNA-seq da
　　Background: RNA-seq is made possible by the latest NGS technology and is most powerful method to analysis gene expression.RNA-seq used the count of reads fa
会议
RNA-seqvariance decompositionmixed linear modeling
Detecting un-occurred disease states for complex diseases by dynamical network biomarkers
　　Considerable evidence suggests that during the progression of complex diseases, the deteriorations are not necessarily smooth but are abrupt, and may cause
会议
SMAL A Resource of Spontaneous Mutation Accumulation Lines
　　Background: Mutation is the ultimate source of genetic variation and evolution.Mutation accumulation (MA) experiments offer an alternative approach to study
会议
Mutation accumulation (MA) experimenthigh-throughput sequencingSMAL
Systematic Analysis of HSP60-Mediated Protein Interaction Network and Metabolic Pathways
　　Background: The molecular chaperone heat shock protein 60 (HSP60) play a crucial role for the maintenance of mitochondrial integrity and protein homeostasis
会议
protein interaction networkquantitative proteomicsmetabolic flux
Prediction of cancer associated miRNAs based on gene expression
　　microRNAs (miRNAs) are a class of short non-coding RNAs that play important roles in post-transcriptional regulations and various biological processes.Recen
会议
cancergene expressionmicroRNA
The comprehensive transcriptome and genome annotation of Bacillus licheniformis WX-02
　　Background: Bacillus licheniformis WX-02 (B.licheniformis WX-02) is a gram-positive bacterium that has been used in industrial production for poly-γ-glutam
会议
B.licheniformis WX-02genometranscriptomestrand-specific RNA-seqdifferentiall
Big Data and its Application in the Pharmaceutical Industry
　　In 2012, the Obama administration announced the Big Data Research and Development Initiative, which explored how big data could be used to address important
会议
SecReT4a web-based bacterial type Ⅳ secretion system resource
　　Background: Bacterial type Ⅳ secretion systems (T4SSs) are versatile assemblages that promote genetic exchange and/or effector translocation with consequen
会议
type Ⅳ secretion systemgene cluster predictioneffector protein detectiontext
Intrinsic correlation of oligonucleotides and its application in metagenome analysis
　　Background: Metagenomics [1], a burgeoning subject of studying microbes by sequencing environmental samples directly, is proposed on account of the vast maj
会议
metagenomicssequence featurebinningsample classification