Bisphenol A (BPA), a well known environmental.estrogen, has biotoxic and endocrine-disrupting effects, wildly exits in environmental, biological and foodstuff samples at a trace amount.So it is necessary to develop a fast, sensitive, high selective and cheap method for determination BPA in complex sample matrices.Molecular imprinted technology is based on the molecular recognition theory, and its main procedure is to synthesize molecular imprinted polymers(MIPs).MIPs have selective combination with the target analyte, so a new high selective, fast and effective sample pretreatment technique-molecular imprinted solid-phase extraction (MISPE) are formed by combination of molecular imprinted technology and solid-phase extraction (SPE), and have been widely used in environmental, biological and clinical samples.In this paper, a new analytical method was developed to determine BPA in different environmental, biological and foodstuff samples based on highly effective capillary electrophoresis (CE) coupled with highly selective MISPE.