铜绿假单胞菌中GGDEF蛋白PA0847的研究

来源 :中国生物化学与分子生物学会2016年全国学术会议 | 被引量 : 0次 | 上传用户：Shauphei

【摘要】

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【作者】

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张燕陈一帆郭嘉义黄卫东

【机构】

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宁夏医科大学基础医学院,银川,750004 宁夏医科大学医学科学研究所,银川,750004

【出处】

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中国生物化学与分子生物学会2016年全国学术会议

【发表日期】

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2016年3期

【关键词】

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环鸟苷二磷酸铜绿假单胞菌鸟苷酸环化酶 PA0847

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　　作为一种广泛存在于细菌中的新型第二信使,关于环鸟苷二磷酸(c-di-GMP)的研究近些年取得了引人注目的进展.对于细菌的多种细胞功能,如生物膜合成、运动性、耐药性、细菌毒性及其细胞周期,小分子的环鸟苷二磷酸都有着很大作用及影响.在细菌胞内,环鸟苷二磷酸的代谢是由两种催化功能相反的酶共同起作用：鸟苷酸环化酶(Diguanylate cyclase,DGCs)将两分子GTP转化生成一分子C-di-GMP；而环鸟苷二磷酸特异的磷酸二酯酶(Phosphodiesterase,PDEs)则将C-di-GMP分解为pGpG,并最终水解为GMP.本实验室对铜绿假单胞菌PAO1中的GGDEF蛋白PA0847进行了分析研究.重组蛋白及高效液相色谱分析显示其具有环化酶活性；点突变及结构分析将有助于揭示其催化作用及可能的调控机制.

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铜绿假单胞菌中GGDEF蛋白PA0847的研究

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