TGF β1 induce overexpression of LSD1 and partially promote EMT through LSD1 in human gastric cancer

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:logepark
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  Epithelial-mesenchymal transition(EMT)is a crucial process in embryonic development and carcinoma progression.Downregulating epithelial markers and disassembling cell-cell adhesions in this transition lead to the loss of cell polarity lose and enhancement of cell migration and invasion.
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Lysine specific demethylase 1(LSD1)plays an important role in the epigenetic control of gene expression and it has been found overexpressed in various tumor tissues.
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