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Background: Cancer biomarker plays an important role in detecting cancer as well as the mechanism of cancer occurrence and development.With the development of transcriptomics research, especially the widely used high-throughput microarray chip and RNA sequencing technology, researchers have obtained a large number of tumor related data and information on he transcriptional level.With such a mass of data and information, how to identify clinical biomarkers systematically and efficiently has become one of advanced research projects of cancer biomarker research.