论文部分内容阅读
A BRISC-SHMT Complex Deubiquitinates IFNAR1 and Regulates Interferon Responses
【作 者】
：
【机 构】
：
Department of Animal Biology and Mari Lowe Comparative Oncology Center,School of Veterinary Medicine
【出 处】
：
中国病理生理学会第十四届肿瘤专业委员会、第十五届免疫专业委员会联合学术会议
【发表日期】
：
2014年4期
其他文献
Fra-1 Mediates Interleukin-6 Induced Epithelial-Mesenchymal Transition in Human Colorectal Cancer Ce
会议
Aqueous extract of Trametes robiniophila murr(Huaier)has been applied for cancer complementary therapy in recent decades.Varies studies have reported that Huaier possess the anti-tumor effects.However
Increased Expression of EIF5A2,via Hypoxia or Gene Amplification,Contributes to Metastasis and Angio
Background & Aims: Solid tumors often become hypoxic,leading to activation of hypoxia-response genes.We investigated the effects of overexpression of the hypoxia response genes eIF5A2 (eukaryotic init
Non-enzymatic action of RRM1 protein upregulates PTEN and E-cadherin leading to inhibition of colore
Ribonucleotide reductase large subunit M1 (RRM1) forms a holoenzyme with small subunits to provide deoxyribonucleotides for DNA synthesis and cell proliferation.Here,we reported a non-RR role of the c
会议
目的:NR2F2(nuclear receptor subfamily 2,group F,member 2)的表达产物为类固醇/甲状腺激素核受体家族成员,在细胞内作为配体诱导的转录因子存在;它对一系列的重要信号通路都有调控作用,但其在乳腺癌中的作用尚不明确,本研究旨在探索NR2F2在乳腺癌中的功能,为乳癌防治提供新的思路。方法:对来自GEO和TCGA的多个乳腺癌表达谱数据进行了Kaplan-Me
Objective: Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide which is not eligible for therapy due to resistant to traditional cytotoxic treatment and metasta
肿瘤侵袭和转移与上皮-间质转化(EMT)并促进组织重塑有密切的关系.LSH(Lymphoid specific helicase)是染色体重构蛋白SNF2家族成员之一,与DNA甲基化密切相关,LSH的敲除缺失会引起小鼠发育失常,说明LSH对生物个体生长发育具有重要意义.LSH在鼻咽癌中的生物学功能及作用机制仍然未知.本项目以鼻咽癌为模型,研究LSH在鼻咽癌细胞中生物学功能,并探究其可能的作用机制.
βⅡ-spectrin (SPTBN1) Suppresses Progression of Hepatocellular Carcinoma and Wnt Signaling via Regula
βⅡ-spectrin (SPTBN1) is an adapter protein for Smad3/Smad4 complex formation during TGF-β signal transduction.Forty percent of SPTBN1+/-mice spontaneously develop hepatocellular carcinoma (HCC),and mo
目的:EMT(epithelial-mesenchymal transition)、MET(mesenchymal-epithelial transition)是上皮肿瘤细胞从原发部位转移到新部位,并定植形成新转移灶的两个重要过程.本研究发现氟尿嘧啶处理A549后,细胞顺序发生EMT-MET的变化,同时探究该过程中细胞的功能改变及分子变化。方法:氟尿嘧啶(50uM)处理对数生长期肺癌细胞系A549