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  5. Blocking the mitochondrial permeability transition pore with cyclosporine-a can restore cardioprotec

Blocking the mitochondrial permeability transition pore with cyclosporine-a can restore cardioprotec

来源 :第十二届中国介入心脏病学大会(CIT2014) | 被引量 : 0次 | 上传用户：tuantuan731
【摘 要】
：
Background Ischemic postconditioning (IPO) reduces lethal reperfusion injury under normal conditions,but its effectiveness is blocked by hypercholesterolemia (HC).This study aims to determine whether
【作 者】
：
Wu Nan Li Wenna Shu Wenqi Lyu Yan Jia Dalin 
【机 构】
：
Department of Cardiology,the First Affiliated Hospital of China Medical University,Liaoning,China
【出 处】
：
第十二届中国介入心脏病学大会(CIT2014)
【发表日期】
：
2014年3期
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Background Ischemic postconditioning (IPO) reduces lethal reperfusion injury under normal conditions,but its effectiveness is blocked by hypercholesterolemia (HC).This study aims to determine whether blocking the mitochondrial permeability transition pore (mPTP) with cyclosporine-A (CsA) can restore cardioprotection of IPO in hypercholesterolemic rat heart.
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