Background: Mammography, ultrasound and MRI have been available for over forty years, including constant updates of technology.There is still no universal utilization by women, costs continue to escalate and problems persist like high false positive rates for MRI and high false negative rates for mammography.Collectively these modalities have not been able to put an end to the deaths and disfigurement caused by this disease.Objective: To investigate the efficacy of melding two emerging technologies: pharmacogenomics and modified military digital infrared to establish their capability in diagnosing ultra-small breast cancers as well as other cancers.Design: Analysis of prospectively collected data and biologic material.Setting: Independent Comprehensive Breast Center.Patients: The first 500 patients who elected to proceed with combined genetics test and infrared from November 2006 thru June 2009.Main Outcome Measures: Earlier and correct identification of breast cancer using non-invasive and non-ionizing radiation modalities.Results: Of the first 500 IR patients, 499 were female and 1 male.Of 550 OncoVue patients, 129 opted to undergo IR.A total of 19 were lost to follow-up.Patients who were negative on IR: 419/500 (84%).Of these, 63/419 went to biopsy because of findings of other diagnostic modalities.Of these, 61/63 with negative IR had a negative biopsy.Of two missed, one was the fault of the investigator but was included.In this series 2/500 were false negative (0.4%).The sensitivity was 96% and the specificity was 79%.In total, 46 cancers were identified including five outside the breast (e.g., 2 lung cancers).A total of 92 MRIs were done and in 71/92 patients IR and MRI agreed.Using these two modalities the smallest cancer found was a 4mm invasive cancer.Conclusion: Our objective was met.These two new diagnostic techniques can dramatically lower cost and provide results at least as good as older paradigms.Further research and a multicenter clinical trial are necessary to shift the paradigm of breast cancer diagnosis.