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OBJECTIVE: To explore the safety, efficiency and prognostic factors of vascular recanalization in patients with symptomatic carotid artery total occlusion.METHODS: Sixty two patients with symptomatic carotid artery total occlusion were divided into two groups: antery-intervention therapy group (21 patients) and drug treatment group (41 patients).The major end-point outcome of follow-up survey was the 2-year functional prognosis evaluated by modified Rankin Score (mRS), while the minor one was the cardiovascular events.