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Aim: The study investigated the antihyperglycemic and antihyperlipidemic effects of low-molecular-weight carrageenan(LC)on rats fed a high-fat diet.Methods: Wistar rats were divided into five groups: normal control group(NC),high-fat diet control group(HC),carrageenan-treated control group(CC),1%LC group(1%LC),and 3%LC-groups(3%LC).Body weight,food intake,fecal weight,blood glucose,and serum lipid levels were measured.Results: After 30 days,body weight significantly decreased in the LC-treated groups than in the HC group.Moreover,postprandial blood glucose,total cholesterol,triglyceride,and low-density lipoprotein cholesterol(LDL-C)levels decreased,whereas high-density lipoprotein cholesterol(HDL-C)levels increased,in the LC-treated groups.Conclusions: These data suggest that LC has antihyperglycemic and hypolipidemic effects,compared to carrageenan,probably related to its increased absorption due to its lower molecular weight.