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Objective To investigate and study the relationship between PLCE1 rs2274223 gene polymorphism and susceptibility to esophageal cancer by use of Meta-analysis.Methods The literatures were searched in Wanfang, CNKI, PubMed, CBM, Web of Science, MEDLINE, EMBASE, Springer, Elsevier and Cochrane databases.The databases were searched from the date of January 1st 2004 to April 1st 2014 to collect the case-control studies on PLCE1 polymorphism and susceptibility to esophageal cancer.For the population genotype distributions of both esophagus cancer group and control group, their odds ratios (ORs) and 95% confidence intervals (CIs) were taken as the effect indexes.Disqualified studies were excluded.Odds ratio of PLCE1 rs2274223 genotype distributions in the group of patients with esophageal cancer and the group of healthy control was calculated.The meta-analysis software, RevMan5.0, was applied for heterogeneity test, pooled OR and 95% confidence intervals.At last, sensitivity analysis and publication bias were also explored.Results A total of twelve case-control studies were included.Of the case-control studies selected for this meta-analysis, a total of 9912 esophageal cancer cases and 13023 controls were included.The pooled Odds Ratio of PLCE1 rs2274223 genotype GA vs AA was 1.29 (95%CI=1.17~1.43) , P<0.01、 GG vs AA was 1.65 (95%CI=1.32~2.05) ,P<0.01、 GG/GA vs AA was 1.30 (95%CI=1.16~1.46), P<0.01 and GG vs GA/AA was 1.48 (95%CI=1.22~1.80),P<0.01.The PLCE1 rs2274223 polymorphism was associated with risk of esophageal cancer in all genetic models.In the stratified analysis by ethnicity, and source of controls, no significantly increased risk was observed for the white person.There were no obviously publication bias detected.Conclusion This meta-analysis shows there" s a significantly association between PLCE1 rs2274223 polymorphism and esophageal cancer in Yellow race population.Due to some minor limitations, our findings should be confirmed in further studies.