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目的：探讨癌相关成纤维细胞(CAFs)同食管癌临床病理参数的相关性，建立食管鳞癌(ESCC)来源的CAFs原代培养细胞株，并研究CAFs对T细胞表面抑制分子、增殖、迁移和功能的影响。方法：本实验利用平滑肌肌动蛋白-a (a-SMA)作为鉴定CAFs的标志。
癌相关成纤维细胞分泌TGF-β抑制T细胞功能并促进食管癌进展
【摘 要】
：
目的：探讨癌相关成纤维细胞(CAFs)同食管癌临床病理参数的相关性，建立食管鳞癌(ESCC)来源的CAFs原代培养细胞株，并研究CAFs对T细胞表面抑制分子、增殖、迁移和功能的影响。方法：本实验利用平滑肌肌动蛋白-a (a-SMA)作为鉴定CAFs的标志。
【机 构】
：
郑州大学第一附属医院生物细胞治疗中心;郑州大学第一附属医院肿瘤科 郑州大学第一附属医院生物细胞治疗
【出 处】
：
中国免疫学会第十届全国免疫学学术大会
【发表日期】
：
2015年10期
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