【摘 要】
：
Silica based C 18 stationary phases for reversed phase liquid chromatography (RPLC) are the most popular and useful HPLC stationary phases, but there are several distinct drawbacks in some cases, such
【机 构】
：
Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, the Ch
【出 处】
：
第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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Silica based C 18 stationary phases for reversed phase liquid chromatography (RPLC) are the most popular and useful HPLC stationary phases, but there are several distinct drawbacks in some cases, such as weak retention and poor selectivity for polar compounds, de-wetting in high aqueous mobile phase conditions, peak tailing of basic compounds, etc.Therefore, polar-modified C18 stationary phases including the polar-endcapped and polar-embedded stationary phases were intensively studied and used to resolve the above problems.Herein, we proposed the polar-copolymerized approach for preparation of polar modified RPLC stationary phases, which is very different from the commonly used polar-endcapped and polar embedded methods.
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