Design,Synthesis,and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-M

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：ahehehehehe

【摘要】

：

A series of imidazo[1,2-a]pyridine derivatives against c-Met was designed by means of bioisosteric replacement.1 In our study,a selective,potent c-Met inhibitor,A41 was identified,with IC50 values of

【作者】

：

Chunpu Li Dengyou Zhang Hong Liu

【机构】

：

CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Scie

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Receptor tyrosine kinase c-Met inhibitor imidazo[1 2-a]pyridine metabolic stabil

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　　A series of imidazo[1,2-a]pyridine derivatives against c-Met was designed by means of bioisosteric replacement.1 In our study,a selective,potent c-Met inhibitor,A41 was identified,with IC50 values of 3.9 nM against c-Met kinase and 45.0 nM against c-Met-addicted EBC-1 cell proliferation,respectively.

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Design,Synthesis,and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-M

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