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Objective The standard protocol of perioperative antibiotic use in laparoscopic colectomy for colon cancer remains to be established.Given the ever-increasing number of antibiotic options available, as well as the growing problem of antibiotic resistance, there is a need for research on this important topic.We retrospectively reviewed the clinical data of 43 patients received laparoscopic fight hemicolectomy for colon cancer to investigate the occurrence of perioperative infections following laparoscopic surgery.