高迁移率族蛋白1与补体C5a的交互作用在ANCA诱导的中性粒细胞活化中的研究

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：yuanyuanzhujinbo

【摘要】

：

研究背景:补体C5a在抗中性粒细胞胞浆抗体(ANCA)诱导的中性粒细胞的募集和活化中发挥了重要作用.而上述病理过程正是ANCA相关血管炎发病过程的关键环节.既往研究发现C5a可引起中性粒细胞释放高迁移率族蛋白1 (HMGB1),我们的前期工作已证实患者循环中HMGB1可以反映ANCA相关血管炎的疾病活动度,这提示HMGB1及C5a在ANCA相关血管炎的发病机制中存在一定的交互作用.目的:该研究旨在

【作者】

：

王辰郝健常冬元陈旻

【机构】

：

北京大学第一医院肾内科北京大学肾脏病研究所

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

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高迁移率族蛋白1与补体C5a的交互作用在ANCA诱导的中性粒细胞活化中的研究

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