We demonstrate a systematic strategy to design an epidermal inorganic optoelectronic device,adhering to skin for blood oxygen measurement based on Beer-Lambert law.In order to keep the optical path unchanged due to skin deformation,we propose all-in-one suspension structure for epidermal optoelectronics,integrating AlGaInP-based emitting element,Si-based phtodetector element and interconnects as one island isolated by liquid PDMS.Besides,the device owns the excellent flexibility and stretchability adaptive to skin deformation.