Outcomes of allogeneic transplantation for FLT3-ITD positive acute myeloid leukemia: a systematic re

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  Aims The detection of fetal liver tyrosine kinase 3 (FLT3) internal tandem duplications (ITDs) has been used as a powerful adverse prognostic indicator for acute myeloid leukemia (AML) in any age group.Evidence is mixed regarding the effects of Allo-HSCT in first complete remission (CR) for patients with FLT3/ITD AML.Methods this study provides a systematic review and meta-analysis of FLT3/ITD AML patients receiving HCT.A search of PubMed, Embase, Pubmed, OVID yielded 1706 abstracts, two researchers screening the trials based on inclusion and exclusion criteria, and assessed the methodology quality independently.
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