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  5. Estimating and accounting for tumor purity in the analysis of DNA methylation data from cancer studi

Estimating and accounting for tumor purity in the analysis of DNA methylation data from cancer studi

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：lookingintheeye
【摘 要】
：
The solid tumor sample obtained from clinical practice is always a mixture of different tissue types.As a result,the high-throughput genomics/epigenomics measurements from tumor samples are mixed sign
【作 者】
：
郑小琪 张乃千 吴华君 吴浩 
【机 构】
：
上海师范大学,数学系 潍坊学院,数学系
【出 处】
：
第七届全国生物信息学与系统生物学学术大会
【发表日期】
：
2016年8期
【关键词】
：
Cancer epigenetics DNA methylation tumor purity Statistical model 
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　　The solid tumor sample obtained from clinical practice is always a mixture of different tissue types.As a result,the high-throughput genomics/epigenomics measurements from tumor samples are mixed signals.The tumor "purity",defined as the percentage of cancer cells in a tumor sample,plays an important role in the analysis of these data.It needs to be properly estimated and accounted for in order to obtain correct inference.
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