【摘 要】
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Background: The association between gonorrhea and prostate cancer risk has been investigated widely, but the results remain inconsistent and contradictory.We conducted an updated meta-analysis to obta
【机 构】
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Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
【出 处】
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CUA2015全国泌尿男生殖系统肿瘤专题会议(10th)暨2015年广东省医学会泌尿外科学学术年会
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Background: The association between gonorrhea and prostate cancer risk has been investigated widely, but the results remain inconsistent and contradictory.We conducted an updated meta-analysis to obtain a more precise estimate of this association.Material/Methods: PubMed, EMBASE, and the Cochrane Library were searched for papers up to June 2014 to identify eligible studies.Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the influence of gonorrhea on prostate cancer risk.Results: Twenty-one observational studies (19 case-control and 2 cohort) were eligible, comprising 9965 prostate cancer patients and 118 765 participants.Pooled results indicated that gonorrhea was significantly associated with increased incidence of prostate cancer (OR 1.31, 95% CI 1.14-1.52).The association between gonorrhea and prostate cancer was stronger in African American males (OR 1.32, 95% CI 1.06-1.65) than in Whites (OR 1.05, 95% CI 0.90-1.21).Conclusions: Our findings suggest that gonorrhea is associated with an increased risk of prostate cancer, especially among African American males.These results warrant further well-designed, large-scale cohort studies to draw definitive conclusions.
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