Big Data and Algorithms in Drug Discovery

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:liang672369282
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成纤维细胞生长因子(FGF)与肿瘤的血管形成有着十分密切的关系。英国阿斯利康公司报道了一种新型FGF 受体(FGFR)高选择性抑制剂---AZD4547[1]。此外,美国礼来公司也研发出一类具有乙烯基吲唑类结构的FGFR 抑制剂LY2874455[2]。
Primary liver cancer,also known as human hepatocellular carcinoma(HCC),is the fifth most common cause of cancer mortality and its incidence is increasing worldwide.
成纤维细胞生长因子受体(FGFR)作为一种常见的酪氨酸激酶受体,具有很强的促进细胞增殖和分化的作用。以FGFR 为靶标对肿瘤进行治疗的最有效方法就是研发FGFR 抑制剂药物,尽管已有该类药物上市,但相对于其它生长因子抑制剂来说,FGFR抑制剂相对年轻。
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