1,2,4-Triazoles,as highly privileged heterocyclic scaffolds,have found extensive applications in biological and pharmaceutical fields as well as materials science.Several potent biological activities,such as antihypertensive,antifungal and antibacterial activities,have aroused considerable attention among medicinal chemists.Therefore,the development of one-pot regioselective approach for the efficient construction of 1,2,4-triazole structure is highly desirable.We have disclosed a general and expeditious approach for the metal-free mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles from hydrazones and aliphatic amines under aerobic oxidative conditions.The methodology features readily accessible starting reagents,general and convenient operating conditions,broad substrate scope and high efficiency,and can be easily scaled up to gram scale.The reaction proceeds through cascade C-H functionalization,double C-N bonds formation and oxidative aromatization sequence.