Aim: Epithelial-mesenchymal transition(EMT)plays crucial roles during embryonic development and carcinoma progression,through downregulating epithelial markers and disassembling cell-cell adhesions,resulting in cell polarity lose,enhanced migratory and invasive properties.Snail,a member of zinc finger transcription factors,induces EMT in part by directly repressing E-Cadherin,which is an epithelial marker and a suppressor of tumor invasion.