FLZ Decreased Aβ Production in Mitochondria and Increased ATP Production by Inhibiting γ-secretase i

来源 :2011第二届国际神经科技大会 | 被引量 : 0次 | 上传用户：wMystarw

【摘要】

：

【作者】

：

Xuan Ye Dan Zhang Gengtao Liu Xiaoguang Chen

【机构】

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Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College China

【出处】

：

2011第二届国际神经科技大会

【发表日期】

：

2011年3期

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　　Amyloid precursor protein (APP) metabolism is a key factor in the pathogenesis of Alzheimers Disease (AD) and it has been recently proposed that mitochondria are involved in the biochemical pathway by which amyloid-beta (Aβ) leads to neuronal dysfunction.The Aβ accumulated in mitochondria can decrease the level of cytochrome c oxidase Ⅳ (COX Ⅳ) and attenuate the ATP production consequently.Aβ could be produced by APP metabolism in situ or be uptaken outside of neurons.

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FLZ Decreased Aβ Production in Mitochondria and Increased ATP Production by Inhibiting γ-secretase i

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