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  5. Simulation Study on the Influences of Chain Length on the Shielding Effect of PEGylated Nanoparticle

Simulation Study on the Influences of Chain Length on the Shielding Effect of PEGylated Nanoparticle

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：xiangcool2
【摘 要】
：
Background: The stealth shielding effect of PEGylated nanocarriers is of great importance for their properties including biological targeting and drug activity.Besides its inhibitory action on the ops
【作 者】
：
胡莹 李洋 王举 
【机 构】
：
生物医学工程学院,天津医科大学,天津,300070
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
PEGylated Nanoparticle biomembrane polymer length molecular dynamic simulation 
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　　Background: The stealth shielding effect of PEGylated nanocarriers is of great importance for their properties including biological targeting and drug activity.Besides its inhibitory action on the opsonization of serum proteins, the shielding effect of PEGylation nanoparticles (NPs) lies in the ability of suppressing the bending of membranes.Our current understanding of the stealth shielding effect of PEGylated nanocarriers is still incomplete.In this study, we analyzed the influences of chain length of polyethylene glycol (PEG) on the shielding effect of PEGylated nanoparticles.
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