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目的:探讨米索前列醇(MP)在足月妊娠引产中的最适剂量。方法:将92例妊娠38~41+周的正常孕妇有引产指征者,随机分为3组:A组在阴道后穹窿放MP50μg,每4h加1次至临产;B组在阴道后穹窿放MP50μg,4h后放25μg,如未临产,每2h放25μg1次至临产;C组在阴道后穹窿放MP25μg,每2h放1次至临产。结果:3组总有效率无明显差异,A组引产成功率90.63%,B组成功率90.00%,C组成功率90.00%。3组宫缩异常发生率分别为A组18.75%,B组与C组均为6.67%。结论:阴道放置米索前列醇用于足月妊娠引产是安全、有效的引产方法,但B组的方案更适合于临床应用。
Objective: To investigate the optimal dose of misoprostol (MP) in induction of term pregnancy. Methods: Ninety-two pregnant women with gestational age ranging from 38 to 41 weeks were randomly divided into three groups: group A received MP50μg in the vaginal fornix and fasted once every 4h until labor; group B received MP50μg in vaginal fornix , After 4h put 25μg, if not labor, every 2h put 25μg 1 times to labor; group C in the vaginal fornix put MP25μg, put every 2h to labor. Results: There was no significant difference in the total effective rate between the three groups. The success rate of induction of labor in group A was 90.63%, the success rate of group B was 90.00% and the success rate of group C was 90.00%. The incidence of contractions in group 3 were 18.75% in group A and 6.67% in group B and C, respectively. Conclusion: Vaginal placement of misoprostol for induction of labor during term pregnancy is a safe and effective method of induction of labor. However, the B group is more suitable for clinical application.