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Combined treatment of tumors with different signal pathway inhibitors is considered as an efficient strategy for cancer therapy.NVP-BEZ235 is a dual pan-class Ⅰ PI3K and mTOR kinase inhibitor currently in clinical trial.TNF-α is involved in regulation of cell apoptosis.In the current work, we explored the combined use of BEZ235 and TNF-α on the PIK3CA mutant colorectal cancer (CRC) cell proliferation inhibition.