【摘 要】
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The role of the tumor microenvironment is now realized to be of critical importance during the tumor initiation, angiogenesis, progression and metastasis.Cancer-associated fibroblasts(CAFs) are abunda
【机 构】
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State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking Univer
【出 处】
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2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
论文部分内容阅读
The role of the tumor microenvironment is now realized to be of critical importance during the tumor initiation, angiogenesis, progression and metastasis.Cancer-associated fibroblasts(CAFs) are abundant in the stroma of solid tumor, which are the main source of collager.Both CAFs and collagen can raise the interstitial fluid pressure (IFP) in tumor, which presents a transport barrier that restricts nanoparticle penetration into the deep of tumor, thereby limiting the efficacy of nano-drug delivery vehicles for cancer therapy.
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