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  5. RAC1 Confers Cisplatin Resistance in Esophageal Squamous Cell Carcinoma by Modulating the Warburg Ef

RAC1 Confers Cisplatin Resistance in Esophageal Squamous Cell Carcinoma by Modulating the Warburg Ef

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户：liwang0113
【摘 要】
：
Objective Objectives: Esophageal squamous cell carcinoma(ESCC)occurs with high frequency in China and the prognosis is poor.Although treatment of ESCC has progressed rapidly,development of chemoresist
【作 者】
：
Chunwen Zheng Ruijie Zeng Jinge Gu Lei Xie Liyan Xu Enmin Li 
【机 构】
：
Department of Biochemistry and Molecular Biology,Shantou University Medical College
【出 处】
：
2019中国肿瘤学大会
【发表日期】
：
2019年7期
【关键词】
：
RAC1 Glycolysis Cisplatin Chemoresistance Esophageal squamous cell carcinoma 
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　　Objective Objectives: Esophageal squamous cell carcinoma(ESCC)occurs with high frequency in China and the prognosis is poor.Although treatment of ESCC has progressed rapidly,development of chemoresistance remains a major challenge in treatment efficiency.One of the earlywarning biomarkers,RAC1(Ras-related C3 botulinum toxin substrate 1),has an essential role in cancer progression and development.However,its responsibilities in chemoresistance of ESCC and the underlying mechanisms are largely unknown.Therefore,this study identified the relationship between RAC1 and chemoresistance and further investigated the mechanism of RAC1 in regulating resistant to chemotherapy.
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