【摘 要】
：
Adult hippocampal neurogenesis plays important roles in learning and memory and mood regulation.External factors, such as physical exercise, have been found to modulate adult hippocampal neurogenesis.
【机 构】
：
The State Key Laboratory of Medical Neurobiology,Shanghai Medical College and Institutes of Brain Sc
【出 处】
：
International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Adult hippocampal neurogenesis plays important roles in learning and memory and mood regulation.External factors, such as physical exercise, have been found to modulate adult hippocampal neurogenesis.Voluntary running enhances cell proliferation in the subgranular zone and increases the number of new born neurons in rodents, but underlying mechanisms are not fully understood.In this study, we used BrdU assay to identify proliferating cells and adult-born neurons in C57/BL6 mice after 15 days of voluntary running wheel test.mRNA levels for several neural factors including PEDF, CNTF and Wnt signaling proteins in dentate gyrus,Ammons horn, and cortex were also analyzed by PCR.Our data show that voluntary running for 15 days enhanced adult hippocampal neurogenesis and differentially modulated the expression of neural factors in dentate gyrus.
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