Leucine-rich Repeat 11 of Toll-like Receptor 9 Can Tightly Bind to CpG-containing Oligodeoxynucleoti

来源 :第七届国际分子模拟与信息技术应用学术会议 | 被引量 : 0次 | 上传用户：jiafeicp

【摘要】

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【作者】

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Xichun Pan Chong Wu Jiang Zheng Hong Zhou Junjie Yue Guofu Ding Bin Li Xin Liu Xinchuan Zheng Mengchen Yu Jun Li Weiwei Jiang

【机构】

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Department of Pharmacology, College of Pharmacy, the Third Military Medical University, 400038 Chong

【出处】

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第七届国际分子模拟与信息技术应用学术会议

【发表日期】

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2014年3期

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Background: Leucine-rich repeats (LRR) within the extracellular domain of human TLR9 (hTLRg) mediate binding to CpG ODN.Resultts: LRR11 ofhTLR9 has high affinity for CpG ODN, whereas the mutants of five positivdy charge residues in LRR 11 lack this affinity.Conclusion: LRR11 binds to CpG ODN with high affinity.Significance: LRR11 could be further investigated as an antagonist of hTLRg.

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Leucine-rich Repeat 11 of Toll-like Receptor 9 Can Tightly Bind to CpG-containing Oligodeoxynucleoti

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