【摘 要】
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Cytokines exhibit a pleiotropic effect in the regulation of the immune cell function, tumor growth and antitumor immune responses.A total of 30 patients with colorectal carcinoma were enrolled on this
【机 构】
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Department of Surgery, First Affiliatcd Hospital of Dalian Medical University, Dalian 116011, P.R.Ch
【出 处】
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2015全国糖尿病足综合治疗、北京手足修复与重建学术研讨会
论文部分内容阅读
Cytokines exhibit a pleiotropic effect in the regulation of the immune cell function, tumor growth and antitumor immune responses.A total of 30 patients with colorectal carcinoma were enrolled on this study and their levels of interleukin (IL)-1β , IL-6, IL-8, tumor necrosis factor (TNF)-α,serum granulocyte colony-stimulating factor (sG-CSF) and serum macrophage colony-stimulating factor (sM-CSF) were measured preoperatively using ELISA.Tumor-infiltrating granulocyte (TIG), tumor-associated macrophage (TAM),G-CSF and M-CSF expression in tumor cells were examined using immunostaining, This study revealed abnormal levels of cytokines in patients, including IL-Iβ (1/30, 3.3%),IL-6 (16/30 53.3%), IL-81 (15/30, 50%), TNF-α (4/21, 19%),sG-CSF (17/30, 56.7%) and sM-CSF (4/21, 19%).There was a positive linear correlation between IL-6 and sM-CSF (P=0.017, R=0.517).sG-CSF was significantly associated with a deeper tumor invasion (P=0.039) and a more advanced tumor stage (P=0.023).The granulocyte/lymphocyte (G/L)ratio was associated with abnormal levels of sG-CSF.Logistic univariate analysis revealed that TIGs were a risk factor for lymph node metastasis (0.019) and TAMs were a risk factor for depth of invasion (0.029), but this was not confirmed in logistic multivariate analysis.In conclusion, IL-6, IL-8, sM-CSF and sG-CSF may indirectly promote tumor growth, progression and metastasis by changing the leukocyte populations in the blood and the tumor microenvironment.
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