5-Fluroruracil (5FU) is used as a chemotherapeutic agent in modem medicine.However,due to its low solubility at physiological pH,inclusion complexes of chitosan (CS) with 5FU was used to improve the efficacy of 5FU[1].The CS-5FU inclusion complexes were prepared as 5FU loaded CS microspheres via an in situ self-assembly method (Fig.1).