【摘 要】
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The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation and angiogenesis with malignancy.Since nuclear factor-κB (NF-κB) is a potential sign for inflammation, NF-κB has been a
【机 构】
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Department of Plastic and Reconstruction Surgery, Beijing Luhe Hospital,Capital Medical University,
【出 处】
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2015全国糖尿病足综合治疗、北京手足修复与重建学术研讨会
论文部分内容阅读
The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation and angiogenesis with malignancy.Since nuclear factor-κB (NF-κB) is a potential sign for inflammation, NF-κB has been associated with the progression of disease in various types of cancer.In the present study, we investigated the effect of NF-κB on the IL-6 pathway in gastric carcinoma and their correlation with disease status and prognosis.The mRNA and protein levels of NF-κB, IL-6 and vascular endothelial growth factor (VEGF) were detected by western blotting and reverse transcription (RT) quantitative PCR (RT-qPCR).Using immunohistochemistry, we examined the expression of these proteins in normal and human gastric cancer tissue samples.The concentrations of IL-6 and TNF-α in collected blood samples were measured according to the enzyme-linked immunosorbent assay (ELISA).IL-6 and TNF-α were found to be expressed at high levels in human gastric cancer samples.A positive correlation was found between the expression of IL-6 and NF-κB by immunohistochemical and further correlation analysis.IL-6, NF-κB and VEGF protein and mRNA levels increased significantly in gastric cancer tissue compared with those in adjacent normal mucosa tissue samples.In conclusion, our findings demonstrate that NF-κ B, IL-6 and VEGF mRNA and protein levels increase significantly in gastric cancer tissues.In addition, the expression of NF-κB was positively correlated with the expression of IL-6 according to immunohistochemical and further correlation analysis, which suggests that the suppression of NF-κB or IL-6 may be a potential target for clinical therapy of gastric cancer in the future.
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